Document Detail

Mammalian cortical astrocytes align themselves in a physiological voltage gradient.
MedLine Citation:
PMID:  8070523     Owner:  NLM     Status:  MEDLINE    
Astrocytes obtained from primary cultures of newborn rat cerebral cortex show a marked structural rearrangement to weak (50-500 mV/mm) applied voltage gradients. Astrocytes reorient their processes so that the cells are aligned perpendicular to the voltage gradient. At field strengths of 100 mV/mm or greater, this realignment occurs in over 90% of the cell population. Furthermore, these magnitudes of electric fields completely eliminate any parallel alignments originally observed prior to application of the voltage. Realignment usually occurs by a withdrawal, followed by an extension, of cell processes. These responses occur at voltage gradients within the physiological range that naturally exist across the neural tube during early development. We suggest the possibility that architectural arrangements of developing glia and, subsequently, neurons may be regulated by endogenous transepithelial potentials that exist across embryonic neuroepithelium.
R B Borgens; R Shi; T J Mohr; C B Jaeger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  128     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-09-23     Completed Date:  1994-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-9     Citation Subset:  IM    
Center for Paralysis Research, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1244.
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MeSH Terms
Animals, Newborn
Astrocytes / metabolism,  physiology
Cells, Cultured
Cerebral Cortex / cytology,  physiology*
Electric Stimulation
Glial Fibrillary Acidic Protein / metabolism
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein

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