Document Detail


Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications.
MedLine Citation:
PMID:  12432923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoxygenases (LOXs) constitute a heterogeneous family of lipid peroxidizing enzymes capable of oxygenating polyunsaturated fatty acids to their corresponding hydroperoxy derivatives. In mammals, LOXs are classified with respect to their positional specificity of arachidonic acid oxygenation into 5-, 8-, 12-, and 15-LOXs. Arachidonate 15-LOXs may be sub-classified into a reticulocyte-type (type-1) and an epidermis-type (type-2) enzyme. Since the leukocyte-type 12-LOXs are very similar to the reticulocyte-type 15-LOXs, these enzymes are designated 12/15-LOXs. Several LOX isoforms, in particular the reticulocyte-type 15-LOX and the human 5-LOX, are well characterized with respect to their structural and functional properties On the other hand, the biological role of most LOX-isozymes including the reticulocyte-type 15-LOC is far from clear. This review is intended to summarize the recent developments in 15-LOX research with particular emphasis to molecular enzymology and regulation of gene expression. In addition, the major hypotheses on the physiological and patho-physiological roles of 15-LOXs will be discussed briefly.
Authors:
Hartmut Kuhn; Matthias Walther; Ralf Jürgen Kuban
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  68-69     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-11-15     Completed Date:  2003-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-90     Citation Subset:  IM    
Affiliation:
Institute of Biochemistry, University Clinics Charité, Humboldt University, Berlin, Germany. hartmut.kuehn@charite.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonate 15-Lipoxygenase / chemistry*,  genetics,  metabolism*
Arachidonic Acid / metabolism
Arteriosclerosis / metabolism
Asthma / metabolism
Catalytic Domain
Cell Differentiation / physiology
Gene Expression Regulation, Enzymologic
Humans
Inflammation / metabolism
Models, Molecular
Neoplasms / metabolism
Protein Binding
Protein Structure, Tertiary
Chemical
Reg. No./Substance:
506-32-1/Arachidonic Acid; EC 1.13.11.33/Arachidonate 15-Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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