Document Detail

Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.
MedLine Citation:
PMID:  12356739     Owner:  NLM     Status:  MEDLINE    
Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and its mammalian homolog is expressed in a variety of differentiating tissues. Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinoic acid receptor and activation transcription factor-2 (ATF-2). In addition, antisense oligonucleotide treatment of embryonic mouse lung explants suggests that Rcd1 also plays a role in retinoic acid-controlled lung development.
Noriko Hiroi; Takaaki Ito; Hanako Yamamoto; Takahiro Ochiya; Shigeki Jinno; Hiroto Okayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The EMBO journal     Volume:  21     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-01     Completed Date:  2002-12-04     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  5235-44     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
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MeSH Terms
Cell Differentiation / drug effects,  physiology*
HL-60 Cells
K562 Cells
Polymerase Chain Reaction / methods
Recombinant Proteins / metabolism
Transcription Factors / genetics,  metabolism*
Tretinoin / pharmacology*
Tumor Cells, Cultured
Reg. No./Substance:
0/RQCD1 protein, human; 0/Recombinant Proteins; 0/Transcription Factors; 302-79-4/Tretinoin

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