Document Detail


Malonyl-CoA: the regulator of fatty acid synthesis and oxidation.
MedLine Citation:
PMID:  22833869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. Subsequent experiments have borne out this finding and furthered our understanding of molecular metabolism.
Authors:
Daniel W Foster
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-24     Completed Date:  2012-08-20     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1958-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, University Of Texas SW Medical Center, Dallas, Texas 75390-9030, USA. daniel.foster@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acids / biosynthesis*,  genetics
Humans
Malonyl Coenzyme A / genetics,  metabolism*
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Fatty Acids; 524-14-1/Malonyl Coenzyme A
Comments/Corrections

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