Document Detail


Malonyl CoA control of fatty acid oxidation in the newborn heart in response to increased fatty acid supply.
MedLine Citation:
PMID:  17218986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of fatty acids in the blood or perfusate is a major determinant of the extent of myocardial fatty acid oxidation. Increasing fatty acid supply in adult rat increases myocardial fatty acid oxidation. Plasma levels of fatty acids increase post-surgery in infants undergoing cardiac bypass operation to correct congenital heart defects. How a newborn heart responds to increased fatty acid supply remains to be determined. In this study, we examined whether the tissue levels of malonyl CoA decrease to relieve the inhibition on carnitine palmitoyltransferase (CPT) I when the myocardium is exposed to higher concentrations of long-chain fatty acids in newborn rabbit heart. We then tested the contribution of the enzymes that regulate tissue levels of malonyl CoA, acetyl CoA carboxylase (ACC), and malonyl CoA decarboxylase (MCD). Our results showed that increasing fatty acid supply from 0.4 mmol/L (physiological) to 1.2 mmol/L (pathological) resulted in an increase in cardiac fatty acid oxidation rates and this was accompanied by a decrease in tissue malonyl CoA levels. The decrease in malonyl CoA was not related to any alterations in total and phosphorylated acetyl CoA carboxylase protein or the activities of acetyl CoA carboxylase and malonyl CoA decarboxylase. Our results suggest that the regulatory role of malonyl CoA remained when the hearts were exposed to high levels of fatty acids.
Authors:
Arzu Onay-Besikci; Nandakumar Sambandam
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  84     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-04-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1215-22     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Pharmacy, Ankara University, Turkey. onay@pharmacy.ankara.edu.tr
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MeSH Terms
Descriptor/Qualifier:
AMP-Activated Protein Kinases
Acetyl Coenzyme A / metabolism
Acetyl-CoA Carboxylase / metabolism
Animals
Animals, Newborn
Carboxy-Lyases / metabolism
Carnitine O-Palmitoyltransferase / metabolism
Citric Acid Cycle
Dose-Response Relationship, Drug
Glucose / metabolism
Malonyl Coenzyme A / metabolism*
Multienzyme Complexes / metabolism
Myocardium / enzymology,  metabolism*
Oxidation-Reduction
Palmitic Acid / metabolism*,  pharmacology
Protein-Serine-Threonine Kinases / metabolism
Rabbits
Chemical
Reg. No./Substance:
0/Multienzyme Complexes; 50-99-7/Glucose; 524-14-1/Malonyl Coenzyme A; 57-10-3/Palmitic Acid; 72-89-9/Acetyl Coenzyme A; EC 2.3.1.21/Carnitine O-Palmitoyltransferase; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.9/malonyl-CoA decarboxylase; EC 6.4.1.2/Acetyl-CoA Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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