Document Detail


Malondialdehyde and sulfhydryl groups as biomarkers of oxidative stress in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  22885431     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin associated with oxidative stress. The present study aimed to investigate the presence of oxidative stress in patients with newly diagnosed SLE. SLE patients (n = 36) and control subjects (n = 28) were enrolled in this study. Blood samples were used for malondialdehyde (MDA), sulfhydryl groups (SH) and uric acid determination. MDA levels (µmol/L) were higher in patients (3.9 ± 2.6) than in control subjects (1.6 ± 2.6). SH were significantly lower in SLE patients. The findings suggest that MDA can be a good marker of oxidative stress in SLE.
Authors:
Yenly G Pérez; Lissett Caridad González Pérez; Rita de Cássia M Netto; Domingos S N de Lima; Emerson S Lima
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Revista brasileira de reumatologia     Volume:  52     ISSN:  1809-4570     ISO Abbreviation:  Rev Bras Reumatol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404256     Medline TA:  Rev Bras Reumatol     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  658-660     Citation Subset:  -    
Affiliation:
Universidade Federal do Amazonas.
Vernacular Title:
Malondialdeído e grupo sulfidrila como biomarcadores do estresse oxidativo em pacientes com lúpus eritematoso sistêmico.
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