Document Detail

Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress.
MedLine Citation:
PMID:  23321859     Owner:  NLM     Status:  MEDLINE    
Underlying mechanisms by which air pollutants adversely affect human health remain poorly understood. Oxidative stress has been considered as a potential mechanism that may promote lipid peroxidation by reactive oxygen species, leading to the formation of malondialdehyde (MDA) that is excreted in biofluids (e.g., urine and exhaled breath condensate (EBC)). A panel study was conducted to examine whether concentrations of MDA in EBC and urine were associated, respectively, with changes in air pollution levels brought by the Beijing Olympic air pollution control measures. EBC and urine samples from 125 healthy adults were collected twice in each of the pre-, during-, and post-Olympic periods. Period-specific means of MDA and changes in MDA levels associated with increases in 24-h average pollutant concentrations were estimated using linear mixed-effects models. From the pre- to the during-Olympic period, when concentrations of most pollutants decreased, EBC MDA and urinary MDA significantly decreased by 24% (P<0.0001) and 28% (P=0.0002), respectively. From the during-Olympic to the post-Olympic period, when concentrations of most pollutants increased, EBC MDA and urinary MDA increased by 28% (P=0.094) and 55% (P=0.046), respectively. Furthermore, the largest increases in EBC MDA associated with one interquartile range (IQR) increases in all pollutants but ozone ranged from 10% (95% CI: 2%, 18%) to 19% (95% CI: 14%, 25%). The largest increases in urinary MDA associated with IQR increases in pollutant concentration ranged from 9% (95%: 0.3%, 19%) to 15% (95% CI: 3%, 28%). These findings support the utility of EBC MDA as a biomarker of oxidative stress in the respiratory tract and urinary MDA as a biomarker of systemic oxidative stress in relation to air pollution exposure in healthy young adults. Both EBC and urine samples can be collected noninvasively in the general population.
Jicheng Gong; Tong Zhu; Howard Kipen; Guangfa Wang; Min Hu; Pamela Ohman-Strickland; Shou-En Lu; Lin Zhang; Yuedan Wang; Ping Zhu; David Q Rich; Scott R Diehl; Wei Huang; Junfeng Jim Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-16
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  23     ISSN:  1559-064X     ISO Abbreviation:  J Expo Sci Environ Epidemiol     Publication Date:    2013 May-Jun
Date Detail:
Created Date:  2013-04-19     Completed Date:  2013-10-21     Revised Date:  2014-06-10    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-7     Citation Subset:  IM    
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MeSH Terms
Air Pollutants / analysis*,  urine
Biological Markers / analysis*,  urine
Breath Tests*
Malondialdehyde / analysis*,  urine
Oxidative Stress*
Grant Support
Reg. No./Substance:
0/Air Pollutants; 0/Biological Markers; 4Y8F71G49Q/Malondialdehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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