| Malnutrition in Infancy as a Susceptibility Factor for Temporal Lobe Epilepsy in Adulthood Induced by the Pilocarpine Experimental Model. | |
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MedLine Citation:
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PMID: 21912094 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Malnutrition during the earliest stages of life may result in innumerable brain problems. Moreover, this condition could increase the chances of developing neurological diseases, such as epilepsy. We analyzed the effects of early-life malnutrition on susceptibility to epileptic seizures induced by the pilocarpine model of epilepsy. Wistar rat pups were kept on a starvation regimen from day 1 to day 21 after birth. At day 60, 16 animals (8 = well-nourished; 8 = malnourished) were exposed to the pilocarpine experimental model of epilepsy. Age-matched well-nourished (n = 8) and malnourished (n = 8) rats were used as controls. Animals were video-monitored over 9 weeks. The following behavioral parameters were evaluated: first seizure threshold (acute period of the pilocarpine model); status epilepticus (SE) latency; first spontaneous seizure latency (silent period), and spontaneous seizure frequency during the chronic phase. The cell and mossy fiber sprouting (MFS) density were evaluated in the hippocampal formation. Our results showed that the malnourished animals required a lower pilocarpine dose in order to develop SE (200 mg/kg), lower latency to reach SE, less time for the first spontaneous seizure and higher seizure frequency, when compared to well-nourished pilocarpine rats. Histopathological findings revealed a significant cell density reduction in the CA1 region and intense MFS among the malnourished animals. Our data indicate that early malnutrition greatly influences susceptibility to seizures and behavioral manifestations in adult life. These findings suggest that malnutrition in infancy reduces the threshold for epilepsy and promotes alterations in the brain that persist into adult life. |
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Authors:
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Francisco Romero Cabral; Margareth Rose Priel; Bruno Henrique Silva Araujo; Laila Brito Torres; Eliangela de Lima; Tiago Gurgel do Vale; Felipe Pereira; Henrique Alves de Amorim; Esper Abrão Cavalheiro; Débora Amado Scerni; Maria da Graça Naffah-Mazzacoratti |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-08 |
Journal Detail:
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Title: Developmental neuroscience Volume: - ISSN: 1421-9859 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7809375 Medline TA: Dev Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Departamento de Neurologia e Neurocirurgia, Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, São Paulo, Brasil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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