| Malnutrition during central nervous system growth and development impairs permanently the subcortical auditory pathway. | |
| | |
MedLine Citation:
|
PMID: 22305651 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The brain that grows and develops under the continued influence of malnutrition presents permanent impairment on functioning and neurotransmitter release. The aim of this study was to investigate the chronic effects of neonatal food restriction on neurochemical and neurodynamical aspects within the primary auditory sensory pathway. Our working hypothesis is that neonatal malnutrition may affect the flow of primary sensory information both at a neurochemical and neurodynamical level. To test this hypothesis, three groups of rats were assigned, from birth to 370 days of life, to the following dietary scheme: a well-nourished (WN) group fed ad libitum lab chow diet; an undernourished (UN) group fed 60% of diet consumed by WN group; and a rehabilitated group, undergoing same dietary restriction as undernourished until 42 days of age and thereafter fed ad libitum until the end of the experiment. At 370 days of age, the animals were submitted to brainstem auditory-evoked potentials (BAEPs) recordings and sacrificed for neurochemical evaluation of glutamate release. Undernutrition decreased glutamate release in the cortex, hippocampus, midbrain and brainstem, and significantly increased the latency of BAEP wave V. In addition; the re-establishment of the dietary conditions was not sufficient to reverse the neurochemical and electrophysiological alterations observed in the UN group. Taken altogether, our results suggest that malnutrition imposed at a critical development period caused an irreversible effect within the auditory primary sensory pathway. |
| | |
Authors:
|
Alexandre Batista Penido; Gustavo Henrique de Souza Rezende; Renata Viana Abreu; Antônio Carlos Pinheiro de Oliveira; Patrícia Alves Maia Guidine; Grace Schenatto Pereira; Deoclécio Alves Chianca; André Ricardo Massensini; Tasso Moraes-Santos; Márcio Flávio Dutra Moraes |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nutritional neuroscience Volume: 15 ISSN: 1476-8305 ISO Abbreviation: Nutr Neurosci Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-02-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
|
Languages: eng Pagination: 31-6 Citation Subset: IM |
Affiliation:
|
Laboratório de Nutrição Experimental (LNE), Faculdade de Farmácia, Universidade Federal de Minas Gerais, Minas Gerais, Brasil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association between poor nutritional status and severe depression in Korean cerebral infarction pati...
Next Document: Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and...