Document Detail

Malignant transformation of an optic pathway glioma without prior radiation therapy.
MedLine Citation:
PMID:  20433265     Owner:  NLM     Status:  MEDLINE    
Optic pathway gliomas (OPGs) arise from the optic nerves, optic chiasm, and/or hypothalamus and most commonly occur in childhood. Although these tumors can be quite challenging to manage, they are typically low-grade astrocytomas histologically, most commonly pilocytic astrocytomas. The few previously reported cases of malignant degeneration of an OPG occurred after external beam radiation therapy. The authors report the first case in the English literature of an OPG that transformed from a low-grade astrocytoma, with features most consistent with a pilocytic astrocytoma, to a malignant glioma without any exposure to radiation therapy.
Garrett K Zoeller; Carole D Brathwaite; David I Sandberg
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery. Pediatrics     Volume:  5     ISSN:  1933-0715     ISO Abbreviation:  J Neurosurg Pediatr     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101463759     Medline TA:  J Neurosurg Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-10     Citation Subset:  IM    
Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
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MeSH Terms
Antineoplastic Agents, Alkylating / therapeutic use
Cell Transformation, Neoplastic / pathology*,  radiation effects
Chemotherapy, Adjuvant
Child, Preschool
Combined Modality Therapy
Cranial Irradiation
Dacarbazine / analogs & derivatives,  therapeutic use
Fatal Outcome
Hypothalamus / pathology,  surgery
Magnetic Resonance Imaging
Neoplasms, Radiation-Induced / pathology
Optic Chiasm / pathology,  surgery
Optic Nerve / pathology,  surgery
Optic Nerve Glioma / diagnosis,  drug therapy,  pathology*,  radiotherapy
Radiotherapy, Adjuvant
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 4342-03-4/Dacarbazine; 85622-93-1/temozolomide

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