| Malignant transformation of an optic pathway glioma without prior radiation therapy. | |
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MedLine Citation:
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PMID: 20433265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Optic pathway gliomas (OPGs) arise from the optic nerves, optic chiasm, and/or hypothalamus and most commonly occur in childhood. Although these tumors can be quite challenging to manage, they are typically low-grade astrocytomas histologically, most commonly pilocytic astrocytomas. The few previously reported cases of malignant degeneration of an OPG occurred after external beam radiation therapy. The authors report the first case in the English literature of an OPG that transformed from a low-grade astrocytoma, with features most consistent with a pilocytic astrocytoma, to a malignant glioma without any exposure to radiation therapy. |
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Authors:
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Garrett K Zoeller; Carole D Brathwaite; David I Sandberg |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurosurgery. Pediatrics Volume: 5 ISSN: 1933-0715 ISO Abbreviation: J Neurosurg Pediatr Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-05-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101463759 Medline TA: J Neurosurg Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 507-10 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Alkylating
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therapeutic use Cell Transformation, Neoplastic / pathology*, radiation effects Chemotherapy, Adjuvant Child, Preschool Combined Modality Therapy Cranial Irradiation Craniotomy Dacarbazine / analogs & derivatives, therapeutic use Fatal Outcome Humans Hypothalamus / pathology, surgery Magnetic Resonance Imaging Male Neoplasms, Radiation-Induced / pathology Optic Chiasm / pathology, surgery Optic Nerve / pathology, surgery Optic Nerve Glioma / diagnosis, drug therapy, pathology*, radiotherapy Radiotherapy, Adjuvant |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Alkylating; 4342-03-4/Dacarbazine; 85622-93-1/temozolomide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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