| Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases. | |
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MedLine Citation:
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PMID: 20121363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study. |
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Authors:
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Kristian Aquilina; Thomas E Merchant; Carlos Rodriguez-Galindo; David W Ellison; Robert A Sanford; Frederick A Boop |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurosurgery. Pediatrics Volume: 5 ISSN: 1933-0715 ISO Abbreviation: J Neurosurg Pediatr Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101463759 Medline TA: J Neurosurg Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 155-61 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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pathology,
surgery Cell Transformation, Neoplastic / radiation effects* Child Child, Preschool Combined Modality Therapy Craniopharyngioma / pathology*, radiotherapy*, surgery Female Fibrosis Humans Keratinocytes / pathology Magnetic Resonance Imaging Male Meninges / pathology Neurosurgical Procedures Pituitary Neoplasms / pathology*, radiotherapy*, surgery Radiotherapy / adverse effects* Risk Assessment |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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