Document Detail

Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases.
MedLine Citation:
PMID:  20121363     Owner:  NLM     Status:  MEDLINE    
Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study.
Kristian Aquilina; Thomas E Merchant; Carlos Rodriguez-Galindo; David W Ellison; Robert A Sanford; Frederick A Boop
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery. Pediatrics     Volume:  5     ISSN:  1933-0715     ISO Abbreviation:  J Neurosurg Pediatr     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101463759     Medline TA:  J Neurosurg Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-61     Citation Subset:  IM    
Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom.
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MeSH Terms
Carcinoma, Squamous Cell / pathology,  surgery
Cell Transformation, Neoplastic / radiation effects*
Child, Preschool
Combined Modality Therapy
Craniopharyngioma / pathology*,  radiotherapy*,  surgery
Keratinocytes / pathology
Magnetic Resonance Imaging
Meninges / pathology
Neurosurgical Procedures
Pituitary Neoplasms / pathology*,  radiotherapy*,  surgery
Radiotherapy / adverse effects*
Risk Assessment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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