| Malignant transformation in Paget disease of bone. | |
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MedLine Citation:
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PMID: 1451058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The previously reported incidence of malignant transformation of Paget disease up to 5.5% and its dismal prognosis have prompted the clinical investigation of a large population with Paget disease. METHODS: A chart review of symptomatic and asymptomatic patients with a diagnosis of Paget disease between 1970 and 1985 at four large Montreal Hospitals revealed 1078 patients. Eight patients with malignant transformation were studied in detail. RESULTS: The incidence of malignant transformation was 0.7%, and the most frequent histologic type was osteogenic sarcoma. The most prevalent site was the femur, and pathologic fracture with focal osteolysis was present in 50% of patients at the initial appearance of the tumor. Healing at the fracture site was demonstrated in one patient. Another patient died of uncontrollable hemorrhage. A case of malignant lymphoma in Paget disease is recorded. CONCLUSIONS: Surgery or biopsy should be preceded by preoperative scintigraphic bone blood flow evaluation and, if necessary, administration of a preoperative course of mithramycin and selective embolization to minimize bleeding. The prognosis of malignant transformation in Paget disease is poor, although one patient with malignant lymphoma survived after aggressive treatment. Early biopsy and aggressive treatment should not be delayed. |
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Authors:
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A Hadjipavlou; P Lander; H Srolovitz; I P Enker |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Cancer Volume: 70 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-06 Completed Date: 1993-01-06 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2802-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Orthopedic Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone Neoplasms / etiology, pathology* Cell Transformation, Neoplastic / pathology* Female Humans Lymphoma / pathology Male Middle Aged Osteitis Deformans / pathology* Osteosarcoma / pathology Retrospective Studies |
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