| Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3. | |
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MedLine Citation:
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PMID: 15994959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Signal transducer and activator of transcription 3 (STAT3) has been indirectly implicated in numerous fundamental cellular processes, including proliferation, survival, and differentiation. We provide genetic evidence from studies of STAT3-null cells that STAT3 is dispensable for normal growth of mouse fibroblasts in culture. STAT3 contributed to the full induction of some (typified by c-fos) but not all (typified by c-myc) immediate early gene expression, but STAT3-independent processes were sufficient to support full cell growth and survival. However, STAT3 was required to manifest a transformed state following expression of v-src, and STAT3-null cells were impaired for anchorage-independent growth as colonies in soft agar and as tumors in mice. The data suggest that STAT3 mediates the maintenance of focal adhesion kinase activity in the absence of cell adhesion by suppressing the action of an inhibitory phosphatase. |
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Authors:
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Karni Schlessinger; David E Levy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 65 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-04 Completed Date: 2005-09-07 Revised Date: 2012-06-05 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 5828-34 Citation Subset: IM |
Affiliation:
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Department of Pathology and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion / genetics Cell Growth Processes / physiology Cell Transformation, Neoplastic / genetics*, metabolism, pathology Cells, Cultured DNA-Binding Proteins / deficiency, genetics* Enzyme Activation Fibroblasts / physiology Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Gene Expression Regulation Genes, fos Genes, src Mice Mice, Inbred BALB C Oncogene Protein pp60(v-src) / biosynthesis, genetics Protein-Tyrosine Kinases / metabolism Proto-Oncogene Proteins c-fos / biosynthesis, genetics STAT3 Transcription Factor Trans-Activators / deficiency, genetics* |
| Grant Support | |
ID/Acronym/Agency:
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AI 28900/AI/NIAID NIH HHS; R01 AI028900-15/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins c-fos; 0/STAT3 Transcription Factor; 0/Stat3 protein, mouse; 0/Trans-Activators; EC 2.7.10.1/Focal Adhesion Kinase 1; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/Focal Adhesion Protein-Tyrosine Kinases; EC 2.7.10.2/Oncogene Protein pp60(v-src); EC 2.7.10.2/Ptk2 protein, mouse |
| Comments/Corrections | |
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