Document Detail


Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.
MedLine Citation:
PMID:  15994959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Signal transducer and activator of transcription 3 (STAT3) has been indirectly implicated in numerous fundamental cellular processes, including proliferation, survival, and differentiation. We provide genetic evidence from studies of STAT3-null cells that STAT3 is dispensable for normal growth of mouse fibroblasts in culture. STAT3 contributed to the full induction of some (typified by c-fos) but not all (typified by c-myc) immediate early gene expression, but STAT3-independent processes were sufficient to support full cell growth and survival. However, STAT3 was required to manifest a transformed state following expression of v-src, and STAT3-null cells were impaired for anchorage-independent growth as colonies in soft agar and as tumors in mice. The data suggest that STAT3 mediates the maintenance of focal adhesion kinase activity in the absence of cell adhesion by suppressing the action of an inhibitory phosphatase.
Authors:
Karni Schlessinger; David E Levy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  65     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-04     Completed Date:  2005-09-07     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5828-34     Citation Subset:  IM    
Affiliation:
Department of Pathology and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion / genetics
Cell Growth Processes / physiology
Cell Transformation, Neoplastic / genetics*,  metabolism,  pathology
Cells, Cultured
DNA-Binding Proteins / deficiency,  genetics*
Enzyme Activation
Fibroblasts / physiology
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Gene Expression Regulation
Genes, fos
Genes, src
Mice
Mice, Inbred BALB C
Oncogene Protein pp60(v-src) / biosynthesis,  genetics
Protein-Tyrosine Kinases / metabolism
Proto-Oncogene Proteins c-fos / biosynthesis,  genetics
STAT3 Transcription Factor
Trans-Activators / deficiency,  genetics*
Grant Support
ID/Acronym/Agency:
AI 28900/AI/NIAID NIH HHS; R01 AI028900-15/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins c-fos; 0/STAT3 Transcription Factor; 0/Stat3 protein, mouse; 0/Trans-Activators; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/Focal Adhesion Kinase 1; EC 2.7.10.2/Focal Adhesion Protein-Tyrosine Kinases; EC 2.7.10.2/Oncogene Protein pp60(v-src); EC 2.7.10.2/Ptk2 protein, mouse
Comments/Corrections

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