Document Detail

Malignant potential in flat elevations.
MedLine Citation:
PMID:  8500371     Owner:  NLM     Status:  MEDLINE    
Ninety-nine colonoscopically removed flat elevations were examined. They were divided into two groups: Group 1--flat elevations 1 to 5 mm in diameter (55 cases)--and Group 2--flat elevations 6 to 10 mm in diameter (44 cases). Group 2 had a higher percentage of adenomas (86.4 percent) than Group 1 (67.3 percent). In adenoma cases (flat adenomas), Group 2 tended to show a higher degree of dysplasia. The rates of mild and moderate dysplasia were 83.8 percent and 16.2 percent in Group 1 vs. 1.70 percent and 13.2 percent in Group 2, respectively. Group 2 contained six cases (15.8 percent) of intramucosal carcinoma (severe dysplasia), while there were no cancer cases in Group 1. Both malignancy rate and degree of dysplasia were size dependent; the larger the lesion the more severe the dysplasia. Our study also revealed that small flat elevations tend to contain higher numbers of nonneoplastic lesions than do larger lesions. Increased detection of nonneoplastic lesions seems to have contributed to an overall decline in the malignancy rate of flat elevations in recent reports.
T Watanabe; T Sawada; Y Kubota; M Adachi; Y Saito; T Masaki; T Muto
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  36     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-29     Completed Date:  1993-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  548-53     Citation Subset:  IM    
Department of Surgery, University of Tokyo, Japan.
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MeSH Terms
Adenoma / pathology
Cell Transformation, Neoplastic
Colonic Polyps / pathology*,  surgery
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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