Document Detail

Malignant potential of the gallbladder in patients with anomalous pancreaticobiliary ductal junction. The difference in risk between patients with and without choledochal cyst.
MedLine Citation:
PMID:  7657495     Owner:  NLM     Status:  MEDLINE    
Anomalous pancreaticobiliary ductal junction (APBDJ) is considered to be a factor developing carcinoma of the biliary tract. However, the difference in clinical significance of APBDJ between patients associated with choledochal cyst and those without cyst with special reference to the malignant potential of the gallbladder has been little studied. Of 1,325 patients examined with direct cholangiography, 29 patients were found to have APBDJ of whom 21 patients were associated with choledochal cyst while eight were not. Their associated hepatobiliary diseases were clinicopathologically examined and compared. The frequencies of carcinoma of the gallbladder in patients without choledochal cyst and in those with cyst were 50% and 5%, respectively, the difference being significant (p < 0.05). This frequency did not depend upon the type of APBDJ. None of the patients with gallbladder carcinoma had gallstones. The overall frequencies of carcinoma of the biliary tract (gallbladder and bile duct) were 14% in patients with cyst and 50% in those without cyst. All were gallbladder carcinoma in the latter group. We conclude that the gallbladder is under the condition with significantly greater malignant potential in patients with APBDJ especially in cases not associated with choledochal cyst. Prophylactic cholecystectomy and excision of cyst if associated should be indicated for patients with APBDJ.
K Chijiiwa; H Kimura; M Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International surgery     Volume:  80     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    1995 Jan-Mar
Date Detail:
Created Date:  1995-09-29     Completed Date:  1995-09-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
Department of Surgery 1, Kyushu University Faculty of Medicine, Fukuoka, Japan.
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MeSH Terms
Choledochal Cyst / complications*
Cholelithiasis / complications
Common Bile Duct / abnormalities*
Gallbladder Neoplasms / etiology*
Middle Aged
Pancreatic Ducts / abnormalities*

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