Document Detail


Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes.
MedLine Citation:
PMID:  19961281     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate clinico-pathological features, treatment, survival, and prognostic factors of patients with malignant ovarian germ cell tumors. DESIGN: Descriptive study. SETTING: Bangkok Metropolitan Administration Medical College and Vajira Hospital and Prince of Songkla University. POPULATION: Malignant ovarian germ cell tumor patients treated between January 1996 and December 2007. METHODS: Clinico-pathological data were collected. Patients with malignant tumors arising from benign cystic teratoma were excluded. Survival and potential prognostic factors were analyzed. MAIN OUTCOME MEASURES: Clinico-pathological features, survival. RESULTS: One hundred and thirty patients were identified. The median age was 21 years (range, 4-44 years). The most common complaint was pelvic or abdominal mass (63%). Primary surgery was performed by a gynecologic oncologist in only 39.2% of cases. More than half (64.2%) had early stage disease (stages I-II) and the majority had conservative surgery (73.1%). The most common histopathology was dysgerminoma. Of 124 patients with available follow-up data, 22 did not receive adjuvant treatment; 1 had whole abdominal radiation; and 101 had chemotherapy. Of 89 patients who were evaluable for responses, 4 patients had progressive disease while 85 had complete response. The five-year progression-free survival (PFS) and overall survival (OS) were 82.4% [95% confidence interval (CI), 75.4-89.5%)] and 92.4% (95% CI, 87.6-97.2%), respectively. Only preoperative tumor marker elevation was a significant poor prognostic factor for PFS. CONCLUSIONS: Malignant ovarian germ cell tumors have a good prognosis with conservative surgical treatment. Chemotherapy is important. Elevated preoperative serum tumor markers are a poor prognostic factor for PFS.
Authors:
Siriwan Tangjitgamol; Jitti Hanprasertpong; Sumonmal Manusirivithaya; Virach Wootipoom; Thaovalai Thavaramara; Rakchai Buhachat
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  89     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-03-04     Revised Date:  2010-04-07    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  182-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, 681 Samsen Road, Dusit District, Bangkok 10300, Thailand. siriwanonco@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Chemotherapy, Adjuvant
Child
Child, Preschool
Chorionic Gonadotropin, beta Subunit, Human / blood
Disease-Free Survival
Female
Humans
L-Lactate Dehydrogenase / blood
Neoplasm Recurrence, Local / pathology
Neoplasms, Germ Cell and Embryonal / mortality*,  pathology*,  therapy
Ovarian Neoplasms / mortality*,  pathology*,  therapy
Prognosis
Radiotherapy, Adjuvant
Survival Rate
Tumor Markers, Biological / blood
Young Adult
alpha-Fetoproteins / analysis
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins; EC 1.1.1.27/L-Lactate Dehydrogenase

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