Document Detail

Malignant mesothelioma with a pronounced myxoid stroma: a clinical and pathological evaluation of 19 cases.
MedLine Citation:
PMID:  16021506     Owner:  NLM     Status:  MEDLINE    
Mesothelioma with a pronounced myxoid stroma has been identified as a morphological pattern that might portend a better prognosis. Reports on this type of cases are few. Its clinical and pathological features are not defined. In this study, we identified 19 such cases from a series of 234 pleural mesotheliomas and performed a comprehensive clinical and pathological analysis. The inclusion criteria were mesotheliomas with at least 50% of the tumor exhibiting a pronounced myxoid stroma that occupied more than 50% of the tumor volume (designated as myxoid mesothelioma). There were ten males and nine females, with a median age of 58 years. Forty seven percent of the patients had probable or definite asbestos exposure. Patients presented at various stages [International Mesothelioma Interest Group (IMIG) stage II, 4; stage III, 9; and stage IV, 6]. Most (16/19) patients were treated by extrapleural pneumonectomy with adjuvant radiation or chemotherapy or both. Overall, the median survival rate was 36 months (median follow-up time, 17 months), and the 2-year survival rate was 79%. Histologically, the tumor cell component was entirely epithelioid without significant cytologic atypia. The myxoid material stained positive for Alcian blue, and the staining diminished after treatment with hyaluronidase in 12 of 12 cases. The tumor cells showed a typical mesothelial immunophenotype. Ultrastructurally, all six tumors examined had typical mesothelial-type surface microvilli and a moderately electron-dense extracellular amorphous material that often formed a haze enmeshing the surface microvilli. Hyaluronic acid-type, fern-like crystals were noted in all cases. These findings show that myxoid mesotheliomas represent a group of epithelioid mesotheliomas that have retained the secretory activity of normal mesothelium. Patients may present at different stages, but survival appears to be superior to that of epithelioid mesotheliomas in general. Our study emphasizes the need for better attention to histologic subtypes, particularly in the context of prognostically or therapeutically oriented investigations of this lethal disease.
Jinru Shia; Jing Qin; Robert A Erlandson; Roy King; Peter Illei; Jennifer Nobrega; Davis Yao; David S Klimstra
Related Documents :
336176 - Chemotherapy of malignant mesothelioma.
16714696 - Management of malignant mesothelioma by decortication and adjunct phototherapy.
21344976 - The sequential use of carmustine wafers (gliadel®) and post-operative radiotherapy with...
21868546 - The efficacy of gemcitabine as salvage treatment in patients with refractory advanced c...
11979306 - Thalidomide as salvage therapy for vad-refractory multiple myeloma prior to autologous ...
10849316 - Reactive follicular hyperplasia in the lymph node lesions from systemic lupus erythemat...
Publication Detail:
Type:  Journal Article     Date:  2005-07-14
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  447     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-30     Completed Date:  2006-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  828-34     Citation Subset:  IM    
Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Immunoenzyme Techniques
Mesothelioma / metabolism,  mortality,  pathology*
Middle Aged
Mucus / metabolism
Neoplasm Staging
Pleural Neoplasms / metabolism,  mortality,  pathology*
Stromal Cells / metabolism,  pathology,  ultrastructure
Survival Rate
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Co-deposition of amyloidogenic immunoglobulin light and heavy chains in localized pulmonary amyloido...
Next Document:  Pyothorax-associated lymphoma: an unusual case with both T- and B-cell genotypes.