Document Detail

Malignant melanoma (stage 1): a clinical trial of adjuvant BCG immunotherapy.
MedLine Citation:
PMID:  752875     Owner:  NLM     Status:  MEDLINE    
A prospectively controlled randomized clinical trial of adjuvant BCG immunotherapy in patients with stage 1B malignant melanoma (Clark's level 3--5) is described. The combination of intradermal and oral BCG allows approximation of the bacilli to any microscopic foci of residual disease. The trial was activated in May 1975 and to date 107 patients have been admitted to the trial, 49 patients being randomil entered patients, there have been five relapses of 49 patients in the treatment group and ten relapses of 58 patients in the control group. This encouraging trend is not yet statsitically significant at the 5% level (P = 0.17). If evaluable patients with Clark's level 3 and 4 lesions are assessed separately, there is a significant trend in favour of the immunotherapy group (P less than 0.05) with three relapses in the treatment group and ten relapses in the control group.
A H Paterson; D Willans; L M Jerry; T A McPherson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer     Volume:  68     ISSN:  0080-0015     ISO Abbreviation:  Recent Results Cancer Res.     Publication Date:  1978  
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0044671     Medline TA:  Recent Results Cancer Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
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MeSH Terms
BCG Vaccine / therapeutic use*
Melanoma / pathology,  therapy
Reg. No./Substance:
0/BCG Vaccine

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