Document Detail


Malignant melanoma (stage 1): a clinical trial of adjuvant BCG immunotherapy.
MedLine Citation:
PMID:  752875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospectively controlled randomized clinical trial of adjuvant BCG immunotherapy in patients with stage 1B malignant melanoma (Clark's level 3--5) is described. The combination of intradermal and oral BCG allows approximation of the bacilli to any microscopic foci of residual disease. The trial was activated in May 1975 and to date 107 patients have been admitted to the trial, 49 patients being randomil entered patients, there have been five relapses of 49 patients in the treatment group and ten relapses of 58 patients in the control group. This encouraging trend is not yet statsitically significant at the 5% level (P = 0.17). If evaluable patients with Clark's level 3 and 4 lesions are assessed separately, there is a significant trend in favour of the immunotherapy group (P less than 0.05) with three relapses in the treatment group and ten relapses in the control group.
Authors:
A H Paterson; D Willans; L M Jerry; T A McPherson
Related Documents :
22453675 - Randomized controlled multicenter international clinical trial of self-gripping pariete...
22441975 - Staple-line reinforcement during laparoscopic sleeve gastrectomy using three different ...
7661605 - Crossover study of thalidomide vs placebo in jessner's lymphocytic infiltration of the ...
8201835 - A randomized clinical trial of two single-dose treatments for paucibacillary leprosy.
12168365 - Effect of early induction of hypothermia on severe head injury.
21333545 - Early and delayed stroke after coronary surgery - an analysis of risk factors and the i...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer     Volume:  68     ISSN:  0080-0015     ISO Abbreviation:  Recent Results Cancer Res.     Publication Date:  1978  
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0044671     Medline TA:  Recent Results Cancer Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
BCG Vaccine / therapeutic use*
Humans
Melanoma / pathology,  therapy
Chemical
Reg. No./Substance:
0/BCG Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Causes of failure in surgical arteriovenous anastomoses
Next Document:  Environmental radioactivity in the Faroes in 1977.