Document Detail

Malignant melanoma arising from unusual conjunctival blue nevus.
MedLine Citation:
PMID:  11074819     Owner:  NLM     Status:  MEDLINE    
Cellular blue nevus is an uncommon pigmented tumor in the conjunctiva, where it generally appears as a deep, circumscribed, pigmented conjunctival mass. We report a case of conjunctival blue nevus that clinically resembled primary acquired melanosis and gave rise to conjunctival melanoma. A 41-year-old man developed a diffuse pigmented mass in the inferior fornix of his left eye. Over a 20-year period, he noted slight progression of the pigment. Foci of epibulbar pigmentation were also present. The lesion resembled primary acquired melanosis. Excisional biopsy and adjuvant cryotherapy were performed. Histopathologic examination disclosed an intense infiltrate of heavily pigmented dendritic melanocytes with aggregates of less pigmented plump cells in the substantia propria. The conjunctival epithelium was normal. Malignant cellular features consistent with melanoma were observed in some foci. Cellular blue nevus of the conjunctiva can simulate primary acquired melanosis and can give rise to malignant melanoma. Arch Ophthalmol. 2000;118:1581-1584
H Demirci; C L Shields; J A Shields; R C Eagle
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  118     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-14     Completed Date:  2000-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1581-4     Citation Subset:  AIM; IM    
Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 900 Walnut St, Philadelphia, PA 19107, USA.
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MeSH Terms
Cell Transformation, Neoplastic / pathology*
Conjunctival Neoplasms / pathology*,  surgery
Diagnosis, Differential
Melanoma / pathology*,  surgery
Melanosis / pathology
Nevus, Blue / pathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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