Document Detail

Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis.
MedLine Citation:
PMID:  6638043     Owner:  NLM     Status:  MEDLINE    
Six patients with malignant lymphoma are described, in whom a syndrome that mimicked malignant histiocytosis clinically and pathologically developed as a terminal event. The clinical course was characterized by hepatosplenomegaly, fever, and a rapid fall in all hematologic counts. Survival from onset of this syndrome was less than six weeks. Pathologically, activation of benign histiocytes with marked erythrophagocytosis was seen throughout the reticuloendothelial system. Disseminated lymphoma was also evident but was grossly and microscopically segregated from the erythrophagocytic process. Immunologic and cytochemical studies in two cases indicated the lymphomas to be of peripheral T cell origin, whereas the phagocytic cells had markers characteristic of histiocytes. A likely mechanism for this syndrome is the production of lymphokines (macrophage-activating factors) by neoplastic T lymphocytes.
E S Jaffe; J Costa; A S Fauci; J Cossman; M Tsokos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  75     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  741-9     Citation Subset:  AIM; IM    
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MeSH Terms
Diagnosis, Differential
Lymph Nodes / pathology
Lymphatic Diseases / diagnosis,  pathology*
Lymphoma / diagnosis,  immunology,  pathology*
Middle Aged
Rosette Formation
Splenomegaly / pathology

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