| Malignant insulinoma arising from intrasplenic heterotopic pancreas. | |
| | |
MedLine Citation:
|
PMID: 19454827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: Heterotopic pancreas is defined as ectopic pancreatic tissue without vascular or anatomic continuity with the normal pancreas. The spleen is a rare site of origin. This case report describes a patient with a malignant insulinoma which originated from an intrasplenic heterotopic pancreas. CASE REPORT: A 46-year-old man with three previous episodes of neuroglucopenic and adrenergic symptoms was referred to our hospital. A fasting test was performed and discontinued due to hypoglycemic symptoms. Preoperative studies failed to demonstrate any pancreatic lesions. However, a heterogeneous encapsulated tumor in the spleen was found on MRI. During surgery, only the splenic tumor was found, with neither vascular nor anatomical connections to the normal pancreas. Pathology reported a malignant insulinoma. Insulin and proinsulin were documented by immunohistochemistry. After one year of follow up, the patient is free of symptoms and no recurrent disease has been documented. DISCUSSION: Only seven cases of splenic heterotopic pancreas have been reported, six with cystic mucinous neoplasms. In addition, only one case of a malignant insulinoma arising from heterotopic pancreas has previously been described. This is the second case reported of an insulinoma arising from heterotopic pancreas and the first to originate from intrasplenic heterotopia. |
| | |
Authors:
|
Carmen M Hernández Cárdenas; Ismael Domínguez; Manuel Campuzano; Paulina Bezaury; María Iñiguez-Rodríguez; Armando Gamboa-Domínguez; Luis F Uscanga |
Related Documents
:
|
17659747 - Malignant lymphoma of spleen presenting as acute pancreatitis: a case report. 3556017 - Pancreatitis presenting as pleural effusions: computed tomography demonstration of pleu... 17392627 - Endoscopic ultrasound and percutaneous access for endoscopic biliary and pancreatic dra... 1664147 - Acute pancreatitis and cushing's disease. 20869747 - Template reporting matters--a nationwide study on histopathology reporting on colorecta... 17659747 - Malignant lymphoma of spleen presenting as acute pancreatitis: a case report. |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2009-05-18 |
Journal Detail:
|
Title: JOP : Journal of the pancreas Volume: 10 ISSN: 1590-8577 ISO Abbreviation: JOP Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-05-20 Completed Date: 2009-08-06 Revised Date: 2009-09-18 |
Medline Journal Info:
|
Nlm Unique ID: 101091810 Medline TA: JOP Country: Italy |
Other Details:
|
Languages: eng Pagination: 321-3 Citation Subset: IM |
Affiliation:
|
Department of Surgery, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Tlalpan, México DF, Mexico. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Choristoma
/
pathology*,
surgery Humans Insulinoma / pathology*, surgery Islets of Langerhans* Magnetic Resonance Imaging Male Middle Aged Pancreatic Neoplasms / pathology*, surgery Splenic Diseases / pathology*, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endoscopic management of pancreatic duct disruption following a bullet injury: a case report.
Next Document: A Case of Perforated Pancreatic Pseudocyst Complicated by Acute Myocardial Infarction Successfully T...