| Malignant hyperthermia susceptibility in X-linked muscle dystrophies. | |
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MedLine Citation:
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PMID: 3508709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate malignant hyperthermia (MH) susceptibility in X-linked muscular dystrophies, halothane and caffeine contracture tests were performed on muscle fiber bundles from five patients with Duchenne muscular dystrophy (DMD) and two patients with Becker muscular dystrophy (BMD). Two DMD patients and one BMD patient had positive contracture tests. Since a positive contracture test is currently the best indicator of anesthetic susceptibility in the MH population, and episodes of MH in dystrophic patients have been reported, patients with DMD and BMD may be at risk for developing similar anesthetic complications. Awareness of this potential anesthetic risk is of importance because orthopedic interventions are increasingly more common in these patients. |
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Authors:
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T D Heiman-Patterson; H M Natter; H R Rosenberg; J E Fletcher; A J Tahmoush |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 2 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1986 Nov-Dec |
Date Detail:
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Created Date: 1989-06-23 Completed Date: 1989-06-23 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 356-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, Hahnemann University Hospital, Philadelphia, PA 19102. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Caffeine / diagnostic use Child Halothane / diagnostic use Humans Linkage (Genetics)* Muscle Contraction / drug effects Muscular Dystrophies / genetics* Sex Chromosome Aberrations / genetics* X Chromosome* |
| Chemical | |
Reg. No./Substance:
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151-67-7/Halothane; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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