Document Detail

Malignant hyperthermia: an OR emergency!
MedLine Citation:
PMID:  12025057     Owner:  NLM     Status:  MEDLINE    
Malignant hyperthermia (MH) is a hypermetabolic syndrome triggered in genetically susceptible individuals when certain potent inhalation anesthetics or succinylcholine are administered. The signs of MH include a greatly increased body metabolism, muscle rigidity and eventual hyperthermia that may exceed 110 degrees F. Death can result from cardiac arrest, brain damage, internal hemorrhaging or failure of other body systems. Dantrolene is given until the manifestations of MH abate. The initial dose is 2.5 mg/kg body weight; and repeated as needed. High-risk patients cannot always be identified by history, and preparation of every OR is essential. Supplies of dantrolene and other medications must be kept in the OR area. If MH develops, acting within minutes may save a life.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses     Volume:  20     ISSN:  0741-5206     ISO Abbreviation:  Plast Surg Nurs     Publication Date:  2000  
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8403490     Medline TA:  Plast Surg Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-6     Citation Subset:  N    
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MeSH Terms
Anesthetics, Inhalation / adverse effects
Genetic Predisposition to Disease
Malignant Hyperthermia* / etiology,  genetics,  prevention & control,  therapy
Risk Factors
Reg. No./Substance:
0/Anesthetics, Inhalation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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