Document Detail

Malignant hyperthermia and althesin.
MedLine Citation:
PMID:  890563     Owner:  NLM     Status:  MEDLINE    
General anaesthesia with Althesin was administered on two occasions to a patient who was identified as susceptible to malignant hyperthermia, in whom there was identified familial subclinical myopathy and once in another patient suffering from arthrogryposis multiplex congenita with a history of fever associated with two previous anaesthetics. In the first patient halothane was administered by accident in association with the Althesin, but no hyperpyrexia occurred. In the second instance nitrous oxide-oxygen and halothane were associated purposely with Althesin. In none of these cases was there any rise in temperature, muscle rigor or elevation of the serum CPK level. This experience corroborates the experimental evidence of Hall, et al.10 and Harrison, who reported that Althesin prevented the onset of hyperthermia, and the clinical reports of Page and Judelman. Althesin can be assumed to be an effective anaesthetic for malignant hyperthermia susceptible patients.
N Honda; K Konno; Y Itohda; M Nishino; S Matsushima; S Haseba; Y Honda; Y Gotoh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Canadian Anaesthetists' Society journal     Volume:  24     ISSN:  0008-2856     ISO Abbreviation:  Can Anaesth Soc J     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0371163     Medline TA:  Can Anaesth Soc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  514-21     Citation Subset:  IM    
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MeSH Terms
Alfaxalone Alfadolone Mixture / adverse effects*
Arthrogryposis / surgery
Child, Preschool
Cleft Palate / surgery
Femur / abnormalities,  surgery
Malignant Hyperthermia / etiology*
Pregnanediones / adverse effects*
Reg. No./Substance:
0/Pregnanediones; 8067-82-1/Alfaxalone Alfadolone Mixture

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