Document Detail

Malignant hypertension, fibrinoid deposition, and fibrinogen electrophoresis.
MedLine Citation:
PMID:  2663231     Owner:  NLM     Status:  MEDLINE    
Electrophoretic profiles of the molecular weight distributions of fibrinogen derivatives in blood provide a tool for combined assessment of coagulation and fibrinolysis in the course of vascular disease. Profiles obtained in studies on an experimental model of hypertension and in humans with occlusive vascular disease are discussed. In the experimental studies elevations in the level of cross-linked dimers provided a more reliable means for predicting development of malignant hypertension than did many other criteria, especially near the outset when blood pressure changed to similar degrees in rats with malignant and benign hypertension. Similarly, we find that levels of dimeric and occasionally trimeric forms of fibrinogen are more prominently elevated than degraded forms of fibrinogen in patients with occlusive vascular disease.
B N Dardik; J R Shainoff; R E Chatelain; P M DiBello; C M Ferrario
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cleveland Clinic journal of medicine     Volume:  56     ISSN:  0891-1150     ISO Abbreviation:  Cleve Clin J Med     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8703441     Medline TA:  Cleve Clin J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
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MeSH Terms
Fibrin / analysis
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / analysis*
Hypertension, Malignant / blood*
Molecular Weight
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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