Document Detail


Malignant hypertension is accompanied by marked alterations in chylomicron metabolism.
MedLine Citation:
PMID:  7498998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malignant hypertension (MH) is a severe complication of untreated arterial hypertension that damages the vascular system. It is often accompanied by disturbances in lipid metabolism that could contribute to its pathophysiology. We examined chylomicron metabolism in MH patients using a triglyceride-rich emulsion known to mimic natural chylomicrons when injected into the bloodstream. The emulsion was labeled with [3H]triolein and [14C]cholesteryl oleate and injected intravenously into 15 normolipidemic MH patients aged 29 to 56 years (8 men) for comparison with 17 healthy control subjects. Consecutive plasma samples were taken at regular intervals during 1 hour for determination of the disappearance curves of the labels. The fractional clearance rate of the [3H]triolein emulsion in MH patients was twice as small as that of control subjects (0.061 +/- 0.012 and 0.141 +/- 0.074 min-1, respectively). On the other hand, [14C]cholesteryl oleate fractional clearance rate was not statistically different in MH patients and control subjects (0.032 +/- 0.004 and 0.056 +/- 0.014 min-1, respectively). These results indicate that in MH, lipolysis (measured by the fractional clearance rate of [3H]triolein) is pronounced diminished, whereas the removal of the remnant particles (measured by the fractional clearance rate of [14C]cholesteryl oleate) is not importantly affected. In conclusion, there is an alteration in the circulatory transport of dietary lipids that may be an important component in the vascular disease associated with MH.
Authors:
H Bernardes-Silva; O Toffoletto; L A Bortolotto; M C Latrilha; E M Krieger; F Pileggi; R C Maranhão
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  26     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-16     Completed Date:  1996-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1207-10     Citation Subset:  IM    
Affiliation:
Heart Institute, Medical School Hospital, Faculty of Pharmaceutical Sciences, University of São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cholesterol Esters / metabolism
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cholesterol, VLDL / blood
Chylomicrons / metabolism*
Data Interpretation, Statistical
Dietary Fats / metabolism
Emulsions / administration & dosage
Female
Humans
Hypertension, Malignant / blood,  metabolism*
Injections, Intravenous
Lipolysis
Male
Middle Aged
Models, Biological
Triglycerides / blood,  metabolism
Triolein / metabolism
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Chylomicrons; 0/Dietary Fats; 0/Emulsions; 0/Triglycerides; 122-32-7/Triolein; 303-43-5/cholesteryl oleate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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