| Malignant gastrointestinal stromal tumor of the small intestine complicated with pulmonary tuberculosis during treatment with imatinib mesylate. | |
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MedLine Citation:
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PMID: 15750270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a patient who had a metastatic gastrointestinal stromal tumor (GIST) after previous failed extensive therapy, including multiple surgeries and hepatic artery embolization. Within a few months of starting administration of imatinib mesylate, the patient exhibited a clinical response with grade 3 neutropenia, when pulmonary tuberculosis developed. A c-kit mutation in exon 11 was detected only in metastatic liver specimens. It is unclear whether or not pulmonary tuberculosis may be induced by imatinib mesylate treatment, but caution is warranted in immunocompromised GIST patients. This is the first report of tuberculosis associated with neutropenia during imatinib mesylate treatment. |
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Authors:
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Mototsugu Takashima; Naoya Igaki; Tomokazu Matsuda; Minako Ohyama; Suirin Kanda; Fumihiko Tamada; Takeo Goto |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 44 ISSN: 0918-2918 ISO Abbreviation: Intern. Med. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-03-07 Completed Date: 2005-05-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 114-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Takasago Municipal Hospital, 33-1 Kamimachi, Arai-cho, Takasago 676-8585. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Antineoplastic Agents / administration & dosage, adverse effects* Antitubercular Agents / therapeutic use Combined Modality Therapy Digestive System Surgical Procedures Fatal Outcome Gastrointestinal Stromal Tumors / complications*, diagnosis, therapy Humans Jejunal Neoplasms / complications*, diagnosis, therapy Laparotomy Leiomyosarcoma / complications*, diagnosis, secondary, therapy Liver Neoplasms / diagnosis, drug therapy, secondary Male Middle Aged Neutropenia / chemically induced, complications Piperazines / administration & dosage, adverse effects* Pyrimidines / administration & dosage, adverse effects* Tomography, X-Ray Computed Tuberculosis, Pulmonary / chemically induced, complications*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Antitubercular Agents; 0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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