Document Detail


Malignant fibrous histiocytoma. An electron microscopic study of 17 cases.
MedLine Citation:
PMID:  6269278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ultrastructural findings in 17 cases of malignant fibrous histiocytoma (MFH) are described. The tumors consisted of fibroblast-like cells and histiocyte-like cells in different proportions in different cases. Intermediate, undifferentiated, xanthomatous and multinucleated giant cells were also identified. In 12 of 17 cases myofibroblasts were evident. Acid phosphatase activity was detected cytochemically in the Golgi zone, endoplasmic reticulum and lysosomes (GERL) mainly within histiocyte-like cells, in three cases. These observations indicate that the GERL of the tumor cells are engaged in th formation of lysosomes. The polymorphic cellular composition, including undifferentiated cells, lends support to the concept that the MFH originates from a primitive multipotent undifferentiated mesenchymal cell.
Authors:
M Tsuneyoshi; M Enjoji; N Shinohara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histology     Volume:  392     ISSN:  0340-1227     ISO Abbreviation:  Virchows Arch A Pathol Anat Histol     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  7505137     Medline TA:  Virchows Arch A Pathol Anat Histol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  135-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / analysis
Adult
Aged
Endoplasmic Reticulum / enzymology
Female
Fibroblasts / ultrastructure
Golgi Apparatus / enzymology
Histiocytes / enzymology,  ultrastructure
Histiocytoma, Benign Fibrous / enzymology,  ultrastructure*
Humans
Lysosomes / enzymology
Male
Microscopy, Electron
Middle Aged
Soft Tissue Neoplasms / enzymology,  ultrastructure*
Chemical
Reg. No./Substance:
EC 3.1.3.2/Acid Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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