Document Detail


Malignant diseases and mortality in blood donors infected with human T-lymphotropic virus type 1 in Israel.
MedLine Citation:
PMID:  23642569     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: The natural history of blood donors infected with human T-lymphotropic virus type 1 (HTLV-1) in Israel has never been assessed. The aim of this study was to evaluate the prevalence of malignant disorders and mortality among a cohort of Israelis diagnosed as HTLV-1 carriers during routine blood unit screening. METHODS: This was an observational retrospective cohort study. All HTLV-1 cases among Israeli blood donors between 1995 and 2009 were included. Data regarding malignant diseases were extracted from the Israel National Cancer Registry. Mortality data were extracted from the Israel Population Registry. RESULTS: Between January 9, 1995 and December 31, 2009, 1574497 blood donors were screened for HTLV-1 in the central blood bank services. Of these, 90 were found to be HTLV-1 carriers. This cohort of HTLV-1-infected blood donors was followed for an average of 9.2±6 years. Among them six (6.7%) were diagnosed as having malignant diseases, four of them with adult T-cell leukemia/lymphoma (ATLL). The incidence of ATLL was 0.37 (95% confidence interval 0.13-1.08)/100 HTLV-1 carrier-years. CONCLUSIONS: We found a high rate of malignant diseases among HTLV-1-infected blood donors.
Authors:
Shmuel Stienlauf; Vered Yahalom; Eilat Shinar; Yechezkel Sidi; Gad Segal; Eli Schwartz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-30
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  -     ISSN:  1878-3511     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-5-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Medicine C, Sheba Medical Center, Tel Hashomer, 52621 Israel; The Center of Geographic Medicine, Sheba Medical Center, Tel Hashomer, Israel; Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel. Electronic address: sshmuel@netvision.net.il.
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