Document Detail


Malignant desmoplastic infantile astrocytoma? A case report and review of the literature.
MedLine Citation:
PMID:  23149336     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Desmoplastic infantile astrocytoma (DIA) and ganglioglioma (DIG) are uncommon and generally benign intracranial tumors that typically affect infants. Unusual cases bearing aggressive clinical and malignant histological features have been described in the literature. We report a patient who was diagnosed at the age of 6 weeks with a DIA that relapsed 3 months postoperatively despite gross total resection (GTR). Pathologic examination revealed several mitoses, not only in the primitive neuroectodermal tumor (PNET)-like areas, but also unexpectedly in the predominating spindle cell component. The Ki67 proliferative index within the spindled component was 25%. The tumor continued to grow after initial relapse despite 2 courses of intensive chemotherapy (including vincristine, carboplatin, and temozolomide), but the recurrence was eventually controlled with oral etoposide. Currently, the patient is stable at 9 months after her initial diagnosis. This case illustrates that rare cases of DIA may display malignant histologic features in the typically benign and predominating spindle cell component and behave in an aggressive clinical manner despite GTR. As such, we recommend early and extended clinical follow-up of all DIA and DIG cases.
Authors:
Khalid Al-Kharazi; Chris Gillis; Paul Steinbok; Christopher Dunham
Related Documents :
23826466 - Primary aorto-enteric fistula - a unique complication of poorly differentiated large b-...
3316506 - Creutzfeldt-jakob disease in hong kong. a case report.
20809116 - Clinical risk factors for gastroschisis and omphalocele in humans: a review of the lite...
7674246 - Sj?gren's syndrome in childhood.
4708406 - Population growth in planaria dugesia tigrina (gerard). regulation by the absolute numb...
15551936 - A cumulative review of the range and incidence of significant adverse events associated...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Clinical neuropathology     Volume:  -     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Patterns of family doctor decision making in practice context. What are the implications for medical...
Next Document:  Gs-coupled adenosine receptors differentially limit antigen-induced mast cell activation.