Document Detail

Malignant and corticosteroid-dependent idiopathic anaphylaxis: successful responses to ketotifen.
MedLine Citation:
PMID:  9291418     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Malignant idiopathic anaphylaxis refers to the most severe form of idiopathic anaphylaxis where defined episodes of idiopathic anaphylaxis are not controlled when the prednisone is reduced below at least 60 mg every other day or 20 mg daily. Corticosteroid-dependent idiopathic anaphylaxis refers to patients with idiopathic anaphylaxis who require continuous daily or alternate day prednisone at threshold doses for control of idiopathic anaphylaxis. Ketotifen has been reported to help induce remission in some patients with idiopathic anaphylaxis and has steroid sparing effects in other patients with idiopathic anaphylaxis. METHODS: We present five patients, two with malignant idiopathic anaphylaxis and three with corticosteroid-dependent idiopathic anaphylaxis, who responded to the administration of ketotifen. RESULTS: All five patients, while receiving ketotifen, had a reduction or resolution of their episodes of idiopathic anaphylaxis and prednisone was tapered and discontinued. CONCLUSION: Ketotifen is shown to be successful in inducing remission in two patients with malignant idiopathic anaphylaxis and in three additional patients with corticosteroid-dependent idiopathic anaphylaxis. An additional patient with malignant idiopathic anaphylaxis had prednisone stopped after elective hip surgery.
R Patterson; E J Fitzsimons; A C Choy; K E Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  79     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-23     Completed Date:  1997-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  138-44     Citation Subset:  IM    
Ernest S. Bazley Asthma and Allergic Diseases Center of the Department of Medicine of Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, Illinois 60611, USA.
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MeSH Terms
Adrenal Cortex Hormones / pharmacology*
Anaphylaxis / etiology*,  prevention & control
Anti-Allergic Agents / therapeutic use
Dose-Response Relationship, Drug
Drug Administration Schedule
Ketotifen / therapeutic use
Middle Aged
Prednisone / administration & dosage,  therapeutic use
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Allergic Agents; 34580-13-7/Ketotifen; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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