Document Detail

Malignant calcification is an important unfavorable prognostic factor in primary invasive breast cancer.
MedLine Citation:
PMID:  22897789     Owner:  NLM     Status:  MEDLINE    
AIMS: To explore the clinical characteristics and prognostic value of malignant calcification in operable breast cancer.
METHODS: A total of 721 patients with invasive ductal carcinoma were divided into two groups based on whether malignant calcifications were observed on mammograms. The association of calcification with pathological features and survival were evaluated. The relative importance of each of the potential prognostic variables was tested using a Cox regression analysis.
RESULTS: Compared with tumors without calcification, those with calcification had a larger tumor size, more lymph node involvement, lower estrogen and progesterone receptor expression and higher human epithelial growth factor receptor 2 expression. The 8-year relapse-free survival was lower for patients with calcifications than for those without (77.5 vs 89.2%, P < 0.01). The 8-year overall survival for patients with calcifications was 82.2% compared with 91.9% for those without (P < 0.01). In multivariate analysis, node status, existence of calcification and tumor size were demonstrated to have a prognostic value for relapse-free survival. The node status, existence of calcifications and estrogen receptor status were also prognostic factors for overall survival.
CONCLUSION: Mammographic calcification is a poor prognostic factor for patients with invasive ductal carcinoma. Its prognostic value is second only to axillary node status and greater than the other factors evaluated. Thus, breast cancers with calcifications should be regarded as high risk when determining adjuvant treatment.
Hong Ling; Zhe-Bin Liu; Ling-Hui Xu; Xiao-Li Xu; Guang-Yu Liu; Zhi-Min Shao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-09
Journal Detail:
Title:  Asia-Pacific journal of clinical oncology     Volume:  9     ISSN:  1743-7563     ISO Abbreviation:  Asia Pac J Clin Oncol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-20     Completed Date:  2013-10-17     Revised Date:  2014-01-11    
Medline Journal Info:
Nlm Unique ID:  101241430     Medline TA:  Asia Pac J Clin Oncol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Publishing Asia Pty Ltd.
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MeSH Terms
Breast Neoplasms / complications,  mortality,  pathology*,  therapy
Calcinosis / diagnosis*,  etiology
Carcinoma, Ductal, Breast / complications,  mortality,  secondary*,  therapy
Follow-Up Studies
Liver Neoplasms / complications,  mortality,  secondary*,  therapy
Lung Neoplasms / complications,  mortality,  secondary*,  therapy
Lymph Nodes / pathology*
Lymphatic Metastasis
Middle Aged
Neoplasm Grading
Retrospective Studies
Survival Rate
Erratum In:
Asia Pac J Clin Oncol. 2013 Dec;9(4):383

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