| Malignant blue nevus: a case report and molecular analysis. | |
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MedLine Citation:
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PMID: 12544095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malignant blue nevus is a rare melanocytic tumor that is described by some authors as a variant of malignant melanoma, whereas others regard it as a distinct entity. To our knowledge no molecular studies of this tumor have been performed, although the molecular pathogenesis of conventional melanomas has been extensively described. We present a case of malignant blue nevus that developed in a 15-cm congenital blue nevus on the back of a 41-year-old man. Subsequent regional lymph node and lung metastases developed within 1 and 29 months, respectively. We performed a molecular analysis for loss of heterozygosity on microdissected samples from the spectrum of benign to malignant blue nevus, using a panel of eight genes (MTS1, MXI1, CMM1, p53, NF1, L-myc hOGG1, and MCC), many of which are commonly associated with conventional melanomas. No loss of heterozygosity was detected, despite informativeness in seven genes. We suggest that malignant blue nevus may represent a distinct entity with a different molecular pathway to tumorigenesis than that of conventional melanomas. |
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Authors:
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Shashi M Ariyanayagam-Baksh; Fabien K Baksh; Sydney D Finkelstein; Patricia A Swalsky; John Abernethy; E Leon Barnes |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 25 ISSN: 0193-1091 ISO Abbreviation: Am J Dermatopathol Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-24 Completed Date: 2003-04-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
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Languages: eng Pagination: 21-7 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA. bakshfs@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Combined Modality Therapy DNA Mutational Analysis DNA Primers / chemistry DNA, Neoplasm / analysis Humans Loss of Heterozygosity* Lung Neoplasms / secondary Lymph Nodes / pathology Male Nevus, Blue / genetics*, secondary*, therapy Polymerase Chain Reaction Skin Neoplasms / genetics*, pathology*, therapy Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Neoplasm; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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