Document Detail

Malignant atrophic papulosis (Degros disease). A report of two cases with clinical and histological studies.
MedLine Citation:
PMID:  1259448     Owner:  NLM     Status:  MEDLINE    
Two women had malignant atrophic papulosis that affected the skin only. Immunologic studies showed normal amounts of serum immunoglobulins and complement and normal delayed hypersensitivity skin test results. Fibrinolysis autografts showed complete loss of fibrinolysis within the lesions but normal fibrinolysis in uninvolved skin. Histopathologic studies showed moderate inflammatory infiltration consisting of lymphocytes in addition to the typical cone-shaped regions of necrobiosis. Large amounts of mucin also were seen. Endovasculitis, thrombosis, and perivascular lymphocytic inflammation were noted in the subcutaneous arterioles of the lesions in only one of the patients. Enzyme histochemical studies showed oxidative enzymes, although in reduced amounts, in the epidermal and dermal cells of the affected skin. Electron microscopic studies of lesions showed paromyxovirus-like inclusions in endothelial cells and fibroblasts. The possibility of an unusual viral causation should be examined further.
S A Muller; M Landry
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  112     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  AIM; IM    
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MeSH Terms
Microscopy, Electron
Paramyxoviridae / isolation & purification
Skin / blood supply,  enzymology
Skin Diseases / diagnosis*,  enzymology,  microbiology,  pathology
Thrombosis / diagnosis,  pathology

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