| Malignant acanthosis nigricans. A case report. | |
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MedLine Citation:
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PMID: 8414421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The authors present a case of malignant acanthosis nigricans that has two unusual aspects. The first is involvement of the lid margins with confluent papillomata, causing severe visual impairment, and the second is the association with lung malignancy. METHODS: A 65-year-old Portuguese man presented with decreased vision, papillomatous lid lesions, pruritus, and progressive thickening of the skin of his face, neck, axillae, and inguinal creases. A diagnosis of acanthosis nigricans was made after skin biopsy. Systemic investigations showed a suprahilar mass, and biopsy was positive for squamous cell carcinoma of the lung. RESULTS: The patient underwent excision of papillomata from all four lid margins, and this was repeated 1 year later. He also completed a course of palliative radiotherapy. CONCLUSION: Malignant acanthosis nigricans is rarely associated with lung neoplasms, being more commonly a manifestation of intra-abdominal malignancies. Of note in this case is the extensive ocular involvement and visual impairment. |
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Authors:
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C C Wedge; D S Rootman; W Hunter; G Sibbald |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Ophthalmology Volume: 100 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-11-08 Completed Date: 1993-11-08 Revised Date: 2009-02-26 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1590-2 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Toronto, Ontario. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acanthosis Nigricans
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complications*,
surgery Aged Biopsy Carcinoma, Squamous Cell / complications*, radiotherapy Eyelid Diseases / complications*, surgery Humans Lung Neoplasms / complications*, radiotherapy Male Skin / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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