| Malignancy in Common Variable Immune Deficiency: Report of Two Rare Cases of Gastrointestinal Malignancy and a Review of the Literature. | |
| | |
MedLine Citation:
|
PMID: 22746346 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Patients can develop malignancies due to various reasons including genetic factors, chemical carcinogens, radiation, and defects in their immune system. The immune system is postulated to carry out routine surveillance for malignancy. Patients who have defective immune responses may be susceptible to malignancies due to complicated underlying mechanisms. These include defective immune response to cancer-causing bacteria, transforming viruses, and other defects such as concomitant molecular, cellular and immunoregulatory defects. Common variable immune deficiency (CVID) is characterized by hypogammaglobulinemia, impaired antibody responses and an increased susceptibility to infections. A disorderly immune response, or immune dysregulation, may also lead to autoimmune complications and possibly to malignancy. The treatment of CVID involves infusion of replacement doses of immunoglobulin, either intravenously (IGIV) or subcutaneously (SCIG). However, it is unclear whether adequate replacement of immunoglobulins is sufficient to prevent the increased risk of malignancy seen in this disease. We present two cases of unusual solid tumors complicating CVID treated with adequate doses of intravenous immunoglobulins. In this study we review the occurrence of malignancy in patients with CVID and postulate mechanisms that may be involved indigent to this disease. We will also review the role of replacement immunoglobulin and discuss cancer screening in these high risk individuals. |
| | |
Authors:
|
C Watkins; R Sahni; N Holla; J Litchfield; G Youngberg; G Krishnaswamy |
Related Documents
:
|
18595776 - Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apo... 388946 - Fundamental studies on macrophage migration inhibitory factor(s) in the supernatant fro... 792986 - Potentiation of the macrophage response to migration inhibition factor from fetal calf ... 21744066 - The biology of interleukin-1: emerging concepts in the regulation of the actin cytoskel... 15701586 - Signal transduction pathways in human epidermis. 20957986 - Caspase cascade regulated mitochondria mediated apoptosis in monocrotophos exposed pc12... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-29 |
Journal Detail:
|
Title: Cardiovascular & hematological disorders drug targets Volume: - ISSN: 2212-4063 ISO Abbreviation: Cardiovasc Hematol Disord Drug Targets Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-7-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101269160 Medline TA: Cardiovasc Hematol Disord Drug Targets Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Allergy and Immunology, PO Box 70622 Department of Medicine, Quillen College of Medicine , Johnson City, TN,USA. KRISHNAS@mail.etsu.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of Nicotine on ATPase, Catalase and Calcium Levels in the Presence of Oligoelements in Brain ...
Next Document: A Meta-analysis of The Efficacy and Safety of Cilnidipine in Chinese Patients with Mild to Moderate ...