| Malignancy: Human T-Cell Lymphotropic Virus Type I and Adult T-Cell Leukaemia/Lymphoma. | |
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MedLine Citation:
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PMID: 11399550 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Adult T-cell leukaemia/lymphoma (ATLL) was first identified in Japan in 1977 [1,2]. The causative agent, the human T-lymphotropic virus type I (HTLV-I), was isolated 3 years later by Gallo's group from a patient initially diagnosed as having mycosis fungoides but subsequently reclassified as a case of ATLL [3]. Since this time, much has been discovered about the molecular pathogenesis of the disease. Despite this, treatment of ATLL remains disappointing and the prognosis of acute and lymphoma types poor. In the United Kingdom, cases of ATLL are mainly restricted to people of Afro-Caribbean descent but the disease is of general importance because ATLL has also been reported in non-endemic areas and may possibly spread into other populations via blood transfusion as blood donors in the UK are currently not screened for HTLV-I. |
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Authors:
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RACHEL Pawson |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Hematology (Amsterdam, Netherlands) Volume: 4 ISSN: 1607-8454 ISO Abbreviation: Hematology Publication Date: 1999 |
Date Detail:
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Created Date: 2001-Jun-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708388 Medline TA: Hematology Country: - |
Other Details:
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Languages: ENG Pagination: 11-27 Citation Subset: - |
Affiliation:
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Department of Haematology, Royal Free Hospital, London. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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