| Malignancies in pediatric patients with ataxia telangiectasia. | |
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MedLine Citation:
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PMID: 10199897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with ataxia telangiectasia (AT), known to have an inherent increased susceptibility to the development of cancer, may present with malignancies that are unusual for the patient's age, are often difficult to diagnose clinically and radiographically and respond poorly to conventional therapy. MATERIALS AND METHODS: We reviewed the clinical presentation and imaging studies of 12 AT patients who developed malignancies. RESULTS: Eight of the twelve patients developed non-Hodgkin's lymphoma (CNS, thorax, bone), two developed Hodgkin's disease, and two were diagnosed with gastrointestinal mucinous adenocarcinoma. CONCLUSION: The lymphomas were commonly extra nodal, and infiltrative rather than mass-like. The recognition of the tumors was often delayed due to confusion with the known infectious complications in AT patients. |
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Authors:
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R C Murphy; W E Berdon; C Ruzal-Shapiro; E J Hall; A Kornecki; A Daneman; F Brunelle; J B Campbell |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric radiology Volume: 29 ISSN: 0301-0449 ISO Abbreviation: Pediatr Radiol Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0365332 Medline TA: Pediatr Radiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 225-30 Citation Subset: IM |
Affiliation:
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Babies & Children's Hospital of New York, Department of Radiology, Division of Pediatric Radiology, 3959 Broadway, BHN 3-318, New York, NY 10032, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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complications,
radiography Adenocarcinoma, Mucinous / complications, radiography Adolescent Adult Ataxia Telangiectasia / complications* Child Child, Preschool Female Gastrointestinal Neoplasms / complications, radiography Humans Lymphoma / complications, radiography Male Neoplasms / complications*, radiography Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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