Document Detail

Malignancies in pediatric patients with ataxia telangiectasia.
MedLine Citation:
PMID:  10199897     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with ataxia telangiectasia (AT), known to have an inherent increased susceptibility to the development of cancer, may present with malignancies that are unusual for the patient's age, are often difficult to diagnose clinically and radiographically and respond poorly to conventional therapy. MATERIALS AND METHODS: We reviewed the clinical presentation and imaging studies of 12 AT patients who developed malignancies. RESULTS: Eight of the twelve patients developed non-Hodgkin's lymphoma (CNS, thorax, bone), two developed Hodgkin's disease, and two were diagnosed with gastrointestinal mucinous adenocarcinoma. CONCLUSION: The lymphomas were commonly extra nodal, and infiltrative rather than mass-like. The recognition of the tumors was often delayed due to confusion with the known infectious complications in AT patients.
R C Murphy; W E Berdon; C Ruzal-Shapiro; E J Hall; A Kornecki; A Daneman; F Brunelle; J B Campbell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric radiology     Volume:  29     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  IM    
Babies & Children's Hospital of New York, Department of Radiology, Division of Pediatric Radiology, 3959 Broadway, BHN 3-318, New York, NY 10032, USA.
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MeSH Terms
Adenocarcinoma / complications,  radiography
Adenocarcinoma, Mucinous / complications,  radiography
Ataxia Telangiectasia / complications*
Child, Preschool
Gastrointestinal Neoplasms / complications,  radiography
Lymphoma / complications,  radiography
Neoplasms / complications*,  radiography
Retrospective Studies

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