Document Detail


Malignancies in pediatric patients with ataxia telangiectasia.
MedLine Citation:
PMID:  10199897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with ataxia telangiectasia (AT), known to have an inherent increased susceptibility to the development of cancer, may present with malignancies that are unusual for the patient's age, are often difficult to diagnose clinically and radiographically and respond poorly to conventional therapy. MATERIALS AND METHODS: We reviewed the clinical presentation and imaging studies of 12 AT patients who developed malignancies. RESULTS: Eight of the twelve patients developed non-Hodgkin's lymphoma (CNS, thorax, bone), two developed Hodgkin's disease, and two were diagnosed with gastrointestinal mucinous adenocarcinoma. CONCLUSION: The lymphomas were commonly extra nodal, and infiltrative rather than mass-like. The recognition of the tumors was often delayed due to confusion with the known infectious complications in AT patients.
Authors:
R C Murphy; W E Berdon; C Ruzal-Shapiro; E J Hall; A Kornecki; A Daneman; F Brunelle; J B Campbell
Related Documents :
3998257 - Effects of systemic corticosteroids on post-cryosurgical edema and other manifestations...
11956007 - Clinical, electrophysiological and immunological remissions after thymectomy in myasthe...
22310967 - Etanercept is safely used for treating psoriatic arthritis in a patient complicated wit...
20191017 - Urolithiasis in patients suffering from malignant hematologic diseases.
15488777 - The effect of vitreous presentation during extracapsular cataract surgery on the postop...
10696317 - Ocular alterations in alopecia areata.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric radiology     Volume:  29     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  IM    
Affiliation:
Babies & Children's Hospital of New York, Department of Radiology, Division of Pediatric Radiology, 3959 Broadway, BHN 3-318, New York, NY 10032, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / complications,  radiography
Adenocarcinoma, Mucinous / complications,  radiography
Adolescent
Adult
Ataxia Telangiectasia / complications*
Child
Child, Preschool
Female
Gastrointestinal Neoplasms / complications,  radiography
Humans
Lymphoma / complications,  radiography
Male
Neoplasms / complications*,  radiography
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with...
Next Document:  Hepatic adenomatosis: rapid sequence MR imaging following gadolinium enhancement: a case report.