Document Detail

Malignancies diagnosed during pregnancy and treated with chemotherapy or other modalities (review of 27 cases): multicenter experiences.
MedLine Citation:
PMID:  20973261     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cancer is the second leading cause of death in women of reproductive age. The most common tumors diagnosed during pregnancy are breast and cervix cancer, Hodgkin lymphoma and non-Hodgkin lymphoma, leukemias, and malignant melanoma. The aim of therapy in pregnancy is to give optimal treatment to the mother without harm to the fetus. In the first trimester, organogenesis continues, so chemotherapy should not be given because of increasing risk of spontaneous abortion, fetal malformation, and mortality. We evaluated mostly seen tumors during pregnancy and assessed treatment type and outcome of pregnancy after chemotherapy in our population.
METHODS: We retrospectively analyzed 27 patients who have been treated during pregnancy or after the delivery because of several malignancies.
RESULTS: The tumors associated with pregnancy were breast cancer, hematologic malignancies,gynecologic malignancies, sarcomas, and others. The chemotherapy regimens were given in 17 of 27 patients in the second or third trimester of pregnancy. Four of the patients were diagnosed with cervical cancer, hemangiopericytoma, chronic myeloid leukemia,and breast cancer during the first trimester, so their pregnancies were ended by therapeutic abortion. Although 1 of the 3 fetuses who were exposed to chemotherapy in utero at the second or third trimester was born prematurely and low birth weight was diagnosed in the other 2 fetuses, fetal malformation was not seen in any of them. There were 7 normal and 9 cesarean deliveries. Twenty-three healthy babies survived from 27 pregnancies, of whom 17 babies were exposed to chemotherapeutic agents.
CONCLUSIONS: We reported herein 27 patients with malignancies diagnosed during pregnancy; 17 patients received chemotherapy during the gestational period without any fetal or maternal abnormalities. Because of the low incidence of malignancy during pregnancy, our report is noteworthy.
; Bala Basak Oven Ustaalioglu; Mahmut Gumus; Ali Unal; Kerim Cayir; Ozlem Sever; Ahmet Bilici; Emin Tamer Elkiran; Halit Karaca; Mustafa Benekli; Aziz Karaoglu; Mesut Seker
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  20     ISSN:  1525-1438     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  698-703     Citation Subset:  IM    
Department of Medical Oncology, Dr Lutfi KNrdar Kartal Education and Research Hospital, Istanbul, Turkey.
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MeSH Terms
Antineoplastic Agents / adverse effects,  therapeutic use*
Pregnancy Complications, Neoplastic / drug therapy*,  therapy
Prenatal Exposure Delayed Effects / chemically induced*
Retrospective Studies
Young Adult
Reg. No./Substance:
0/Antineoplastic Agents

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