Document Detail

Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants.
MedLine Citation:
PMID:  17160219     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Since ovarian function is only temporarily compromised by radioiodine therapy, many women with thyroid cancer treated with radioiodine can become pregnant. The present study evaluated the evolution of these pregnancies and the consequences for the offspring. PATIENTS AND METHODS: We retrospectively analyzed 78 pregnancies of 66 women submitted to total thyroidectomy, followed by radioiodine therapy 3.75-5.5 GBq (131)I, mean 4.64 GBq). In all patients, conception occurred one year after ablative therapy (mean of 30 months). Age ranged form 19 to 36 years (mean of 30.6 years) at the time of radioiodine treatment and from 23 to 39 years (mean of 32.8 years) at the time of conception. RESULTS: Four (5.1%) of the 78 pregnancies resulted in spontaneous abortions. Three (4%) of the 74 deliveries were preterm and there was no case of stillbirth. The birthweight was > 2500 g in 94.6% of the children (+/- SD: 3350 +/- 450 g) and only one infant (1.3%) presented an apparent malformation at birth (intraventricular communication). No difference in the age at the time of radioiodine therapy or conception or in radioiodine dose was observed between pregnancies with an unfavorable outcome and those with a favorable outcome. CONCLUSION: We conclude that pregnancies that occur 12 months after ablative therapy are safe.
Pedro Weslley S do Rosário; Alvaro Luís Barroso; Leonardo Lamego Rezende; Eduardo Lanza Padrão; Michelle A Ribeiro Borges; Saulo Purisch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arquivos brasileiros de endocrinologia e metabologia     Volume:  50     ISSN:  0004-2730     ISO Abbreviation:  Arq Bras Endocrinol Metabol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403437     Medline TA:  Arq Bras Endocrinol Metabol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  930-3     Citation Subset:  IM    
Endocrinology and Metabolism Service, Department of Thyroid, Santa Casa de Belo Horizonte, MG.
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MeSH Terms
Abnormalities, Drug-Induced*
Abortion, Spontaneous / chemically induced
Carcinoma / radiotherapy*,  surgery
Infant, Newborn
Infant, Premature
Iodine Radioisotopes / adverse effects*,  therapeutic use
Ovary / radiation effects
Pregnancy Complications, Neoplastic / chemically induced*
Pregnancy Outcome*
Retrospective Studies
Thyroid Neoplasms / radiotherapy*,  surgery
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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