Document Detail

Malformations of cortical development: burdens and insights from important causes of human epilepsy.
MedLine Citation:
PMID:  14693109     Owner:  NLM     Status:  MEDLINE    
Malformations of cortical development (MCD) are important causes of chronic epilepsy in human beings. A blanket term, MCD encompasses many varied developmental disorders with diverse clinical manifestations in patients that neurologists, paediatricians, and learning disability psychiatrists will encounter. Advances in imaging and genetics have led to a significant increase in our understanding of MCD, which has in turn enriched our knowledge of human epileptogenesis and normal brain development and function. In this review, I discuss some of the most common or enlightening MCD: focal cortical dysplasia, periventricular heterotopia, polymicrogyria, band heterotopia and lissencephaly, dysembryoplastic neuroepithelial tumours, and microdysgenesis. Clinical and imaging features, genetic aetiologies, treatments, and the insights that have resulted from MCD study are covered. The burden of epilepsy due to MCD is significant and there is still much to learn about MCD.
Sanjay M Sisodiya
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Lancet. Neurology     Volume:  3     ISSN:  1474-4422     ISO Abbreviation:  Lancet Neurol     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-24     Completed Date:  2004-01-21     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-38     Citation Subset:  IM    
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MeSH Terms
Cerebral Cortex / abnormalities*,  growth & development,  pathology*
Epilepsy / etiology*
Nervous System Malformations / complications*,  pathology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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