Document Detail

Malevamides A-C, new depsipeptides from the marine cyanobacterium Symploca laete-viridis.
MedLine Citation:
PMID:  10785414     Owner:  NLM     Status:  MEDLINE    
Three new depsipeptides, malevamides A-C (1-3), were isolated from the cyanobacterium Symploca laete-viridis collected off the south shore of Oahu, Hawaii. Compounds 1-3 were identified by spectral methods, and partial stereochemical assignments were made by chiral HPLC of the hydrolyzed compounds. At a concentration of 2 microg/mL, compounds 1-3 were inactive against P-388, A-549, and HT-29 cancer cells.
F D Horgen; W Y Yoshida; P J Scheuer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of natural products     Volume:  63     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-23     Completed Date:  2000-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  461-7     Citation Subset:  IM    
Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822, USA.
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MeSH Terms
Antineoplastic Agents / isolation & purification*,  pharmacology
Chromatography, High Pressure Liquid
Cyanobacteria / chemistry*
Drug Screening Assays, Antitumor
Magnetic Resonance Spectroscopy
Peptides, Cyclic / isolation & purification*,  pharmacology
Spectrometry, Mass, Fast Atom Bombardment
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents; 0/Depsipeptides; 0/Peptides, Cyclic; 0/malevamide A; 0/malevamide B; 0/malevamide C

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