Document Detail

Male sex hormones may influence the symptoms of irritable bowel syndrome in young men.
MedLine Citation:
PMID:  18974649     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate the sex hormone status of young male patients with irritable bowel syndrome (IBS) and to investigate whether there were any differences in bowel symptoms related to the hormone levels. METHODS: Thirty-eight young male patients with IBS were compared with 20 healthy young men. Details of symptoms were collected by a structured questionnaire. Each subject underwent a blood test and colonoscopy. The blood test included serum testosterone, free testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone and luteinizing hormone. Based on the questionnaire, patients were classified as having diarrhea-predominant IBS (IBS-D) or constipation-predominant IBS (IBS-C). RESULTS: Among the 38 patients with IBS, 24 had IBS-D and 14 had IBS-C. The patients had higher levels of testosterone and SHBG than did the controls (p = 0.04 and p = 0.03, respectively). However, there was no significant difference between the IBS-D and IBS-C group with regard to the testosterone and SHBG levels (p > 0.05). There was also no difference in the duration and severity of symptoms between these 2 groups (p > 0.05). CONCLUSIONS: Sex hormone status in young men differ from those in older men and may play an important role in the pathophysiology of IBS, regardless of the dominant symptom type.
Beom Jin Kim; Poong-Lyul Rhee; Jung Ho Park; Dong Kyung Chang; Young-Ho Kim; Hee Jung Son; Jae J Kim; Jong Chul Rhee; Hyuk Lee
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-10-31
Journal Detail:
Title:  Digestion     Volume:  78     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-18     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  88-92     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Medicine, Samsung Medical Center, Seoul, Korea.
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MeSH Terms
Follicle Stimulating Hormone / blood*
Irritable Bowel Syndrome / blood*
Luteinizing Hormone / blood*
Sex Hormone-Binding Globulin / analysis*
Testosterone / blood*
Reg. No./Substance:
0/Sex Hormone-Binding Globulin; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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