Document Detail

Male reproductive disorders in humans and prenatal indicators of estrogen exposure. A review of published epidemiological studies.
MedLine Citation:
PMID:  16005180     Owner:  NLM     Status:  MEDLINE    
Male reproductive disorders in humans and prenatal indicators of estrogen exposure. A review of published epidemiological studies. Reports of an increase in male reproductive disorders in several countries led to the hypothesis that estrogens during fetal life may cause reduced sperm counts, cryptorchidism, hypospadias and testicular cancer. So far the hypothesis is based on animal studies and reports from the wild life. We systematically searched the epidemiological literature for evidence linking indicators of prenatal serum levels of maternal estrogens with sperm density, hypospadias, cryptorchidism and testicular cancer in humans. Indicators of fetal estrogen exposure included direct measurements, recorded intake of hormones (diethylstilbestrol (DES), oral contraceptives (OCs) and estrogens), pregnancy conditions with known deviant estrogen level as for instance twin pregnancies and some environmental exposures. Among 425 papers we reviewed 81 publications with appropriate information. With the possible exception of testicular cancer there is no strong epidemiological evidence to indicate that prenatal exposure to estrogen are linked to disturbed development of the male reproductive organs.
Lone Storgaard; Jens Peter Bonde; Jørn Olsen
Publication Detail:
Type:  Journal Article; Review     Date:  2005-07-06
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  21     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-15     Citation Subset:  IM    
Department of Occupational Medicine, University Hospital of Aarhus, Nørrebrogade 44, DK 8000 Aarhus C, Denmark.
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MeSH Terms
Cryptorchidism / etiology
Environmental Exposure*
Epidemiologic Studies
Estrogens / toxicity*
Fertilization / drug effects
Hypospadias / etiology
Prenatal Exposure Delayed Effects*
Sperm Count
Testicular Neoplasms / chemically induced
Reg. No./Substance:

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