Document Detail

Male lower urinary tract symptoms and α(1) (D) -adrenoceptors.
MedLine Citation:
PMID:  23205498     Owner:  NLM     Status:  Publisher    
Historically, α(1) -adrenoceptors have been classified into three subtypes (α(1) (A) , α(1) (B) and α(1) (D) ) that are widely distributed in various organs. Research on the α(1) (D) -adrenoceptors in the bladder, urethra and prostate has focused on the relationship between expression levels and symptoms of bladder outlet obstruction, and the implications and functional roles of α(1) (D) -adrenoceptors subtypes in these organs. The α(1) (D) -adrenoceptor messenger ribonucleic acid and protein seem to be increased in obstructed bladders or small capacity bladders. In contrast, α(1) (D) -adrenoceptor subtype knock-out mice have been found to have a prolonged voiding interval. Interestingly, an α(1) (D) -adrenoceptor antagonist was found to inhibit the facilitation of afferent nerve activity for the micturition reflex induced by intravesical infusion of acetic acid. Clinically, patients who felt urgency at low filling volumes and had a small bladder capacity were found to have more α(1) (D) -adrenoceptor messenger ribonucleic acid in their bladder mucosa than patients who felt urgency at high filling volumes and had a large bladder capacity. An α(1) (D) -adrenoceptor antagonist was found to increase the first desired volume and the maximum desired volume while decreasing detrusor overactivity in pressure flow studies. Thus, α(1) (D) -adrenoceptors in the lower urinary tract might play an important role in the pathophysiology of lower urinary tract disorders.
Osamu Ishizuka; Tetsuya Imamura; Yoshiki Kurizaki; Osamu Nishizawa; Karl-Erik Andersson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  -     ISSN:  1442-2042     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Japanese Urological Association.
Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
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