Document Detail

Male gender promotes an increased inflammatory response to lipopolysaccharide (LPS) in umbilical vein blood.
MedLine Citation:
PMID:  22506729     Owner:  NLM     Status:  Publisher    
Abstract Objectives: To establish gender-specific differences in maternal and fetal immune response in healthy human fetuses at term. Methods: Forty-five women with elective caesarean sections for uncomplicated singleton pregnancies were recruited for two studies. Using a Multiplex Biomarker Immunoassay system, un-stimulated maternal and fetal plasma concentrations of IL-1β, IL-1ra, IL-6, IL-8, MIP-1α, and TNF-α were measured from one study population. LPS-stimulated cytokine response was measured in a second study. Results: There were no significant gender differences in either maternal or fetal un-stimulated plasma cytokine concentrations, but concentrations of the pro-inflammatory cytokines IL-1β and IL-6 were significantly greater in male fetal LPS stimulated samples than in female fetal samples. Conclusions: Blood of male fetuses mounts a larger pro-inflammatory response to LPS. This heightened response could be a critical pathway in promoting PPROM and may be associated with life long differential gender response to infection.
Shunaha Kim-Fine; Timothy Rh Regnault; James S Lee; Sarah A Gimbel; Jill A Greenspoon; Jonathan Fairbairn; Kelly Summers; Barbra de Vrijer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-17
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of Obstetrics and Gynaecology, London, Ontario, Canada, N6A 5W9.
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