| Male-driven evolution of DNA sequences. | |
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MedLine Citation:
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PMID: 8469284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is commonly believed that the mutation rate is much higher in the human male germ line than in the female germ line because the number of germ-cell divisions per generation is much larger in males than in females. But direct estimation of mutation rates is difficult, relying mainly on sex-linked genetic diseases, so the ratio (alpha m) of male to female mutation rates is not clear. It has been noted that if alpha m is very large, then the rate of synonymous substitution in X-linked genes should be only 2/3 of that in autosomal genes, and comparison of human and rodent genes supported this prediction. As the number of X-linked genes used in the study was small and the X-linked and autosomal sequences were non-homologous, and given that the synonymous rate varies among genes, we sequenced the last intron (approximately 1 kb) of the Y-linked and X-linked zinc-finger-protein genes (ZFY and ZFX) in humans, orang-utans, baboons and squirrel monkeys. The ratio Y/X of the substitution rate in the Y-linked intron to that in the X-linked intron is approximately 2.3, which is close to that estimated from synonymous rates in the ZFY and ZFX genes and implies alpha m approximately 6. This estimate of alpha m supports the view that the evolution of DNA sequences in higher primates is male-driven. It is, however, much lower than the previous estimate and therefore raises a number of issues. |
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Authors:
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L C Shimmin; B H Chang; W H Li |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nature Volume: 362 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-05-11 Completed Date: 1993-05-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 745-7 Citation Subset: IM |
Affiliation:
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Center for Demographic and Population Genetics, University of Texas, Houston 77225. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/X58925; X58926; X58930; X58931; X58932; X58935; X58936; X72698 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence DNA DNA-Binding Proteins / genetics* Evolution* Female Humans Kruppel-Like Transcription Factors Male Molecular Sequence Data Mutation* Papio Pongo pygmaeus Saimiri Sequence Homology, Nucleic Acid Sex Factors Transcription Factors X Chromosome Y Chromosome Zinc Fingers / genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Kruppel-Like Transcription Factors; 0/Transcription Factors; 0/ZFY protein, human; 0/zinc finger protein, X-linked; 9007-49-2/DNA |
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