Document Detail

Malarial chemoprophylaxis and the healing of periodontal lesions.
MedLine Citation:
PMID:  1860289     Owner:  NLM     Status:  MEDLINE    
A randomized study was carried out using 92 patients (39 taking a malarial chemoprophylactic agent and 53 not taking a chemoprophylactic agent) to investigate the rate of healing of ulcerative periodontitis after treatment. The chemoprophylaxis group who had been on 300 mg chloroquine weekly for at least one year and the non-chemoprophylaxis group who had not been on the regimen for at least one year were involved in the study which examined the global efficacy and assessment for pain relief over a period of 12 weeks after treatment for ulcerative periodontitis. A detailed, symtomatic and clinical assessment was made at biweekly intervals. Relief from pain was higher for the non-chemoprophylaxis group (94.2% vs. 46.2%, p less than 0.05). The global efficacy was statistically significant for the non-chemoprophylaxis group (87% vs. 38.4%, p less than 0.05). The outcome of treatment was not influenced by factors such as duration of chemoprophylaxis, initial severity of pain and smoking habits of the patients.
S A Ogunwande
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical preventive dentistry     Volume:  13     ISSN:  0163-9633     ISO Abbreviation:  Clin Prev Dent     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-09-04     Completed Date:  1991-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8004895     Medline TA:  Clin Prev Dent     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  D    
Atinike Dental Hospital, Oyo State, Nigeria.
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MeSH Terms
Antimalarials / adverse effects*
Chloroquine / adverse effects,  analogs & derivatives*
Malaria / drug therapy*
Pain / prevention & control
Periodontitis / etiology*
Reg. No./Substance:
0/Antimalarials; 50-63-5/chloroquine diphosphate; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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