| Malaria suppression with fortnightly doses of pyrimethamine with sulfadoxine in the Gambia. | |
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MedLine Citation:
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PMID: 5313064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As it had been shown in previous trials that very small doses of pyrimethamine and sulfadoxine or dapsone were effective in eliminating Plasmodium falciparum in 2 or 3 days, small-scale field trials were carried out on children to investigate the efficacy of this combination of drugs in suppressing malaria.Doses of pyrimethamine 2 mg with sulfadoxine 40 mg, fortnightly, appeared to be completely successful in suppressing seasonal hyperendemic malaria in a group of 38 Gambian children over a 6-month period. On the other hand, pyrimethamine alone at the recommended dose failed to suppress falciparum malaria in some children of another group. Parasite resistance to the sulfonamide-pyrimethamine combination was not encountered nor was there any suggestion of toxicity. It is concluded that these drugs in combination could have a place in malaria chemoprophylaxis. |
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Authors:
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A B Laing |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Bulletin of the World Health Organization Volume: 43 ISSN: 0042-9686 ISO Abbreviation: Bull. World Health Organ. Publication Date: 1970 |
Date Detail:
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Created Date: 1971-03-23 Completed Date: 1971-03-23 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 7507052 Medline TA: Bull World Health Organ Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 513-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Dapsone / administration & dosage* Humans |
| Chemical | |
Reg. No./Substance:
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80-08-0/Dapsone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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