Document Detail

Malaria suppression with fortnightly doses of pyrimethamine with sulfadoxine in the Gambia.
MedLine Citation:
PMID:  5313064     Owner:  NLM     Status:  MEDLINE    
As it had been shown in previous trials that very small doses of pyrimethamine and sulfadoxine or dapsone were effective in eliminating Plasmodium falciparum in 2 or 3 days, small-scale field trials were carried out on children to investigate the efficacy of this combination of drugs in suppressing malaria.Doses of pyrimethamine 2 mg with sulfadoxine 40 mg, fortnightly, appeared to be completely successful in suppressing seasonal hyperendemic malaria in a group of 38 Gambian children over a 6-month period. On the other hand, pyrimethamine alone at the recommended dose failed to suppress falciparum malaria in some children of another group. Parasite resistance to the sulfonamide-pyrimethamine combination was not encountered nor was there any suggestion of toxicity. It is concluded that these drugs in combination could have a place in malaria chemoprophylaxis.
A B Laing
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Bulletin of the World Health Organization     Volume:  43     ISSN:  0042-9686     ISO Abbreviation:  Bull. World Health Organ.     Publication Date:  1970  
Date Detail:
Created Date:  1971-03-23     Completed Date:  1971-03-23     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  7507052     Medline TA:  Bull World Health Organ     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  513-20     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Dapsone / administration & dosage*
Reg. No./Substance:

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