Document Detail

Malaria infection during pregnancy: intrauterine growth retardation and preterm delivery in Malawi.
MedLine Citation:
PMID:  10228088     Owner:  NLM     Status:  MEDLINE    
In sub-Saharan Africa, malaria infection in pregnancy contributes to low birth weight through intrauterine growth retardation (IUGR) and preterm delivery (PTD). It was hypothesized that malaria-associated PTD and IUGR have differing etiologies due to timing of infection. In a prospective cohort of primigravid women enrolled at the antenatal clinic of Mangochi District Hospital in Malawi, the associations were investigated between antenatal or delivery parasitemias and IUGR or PTD. Among 178 singleton deliveries, 35% of infants were preterm or had IUGR. Cord blood parasitemia (odds ratio [OR]=3.34; 95% confidence interval [CI], 1.3-8.8], placental parasitemia (OR=2.43; 95% CI, 1.2-5.1), and postdelivery maternal peripheral parasitemia (OR=2.78; 95% CI, 1.3-6.1) were associated with PTD. Parasitemia and/or clinically diagnosed malaria in the antenatal period was associated with IUGR (OR=5.13; 95% CI, 1.4-19.4). Delivery parasitemias had borderline associations with IUGR. The risk patterns observed suggest that the timing and severity of infection influences the occurrence of IUGR or PTD.
A D Sullivan; T Nyirenda; T Cullinan; T Taylor; S D Harlow; S A James; S R Meshnick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  179     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-21     Completed Date:  1999-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1580-3     Citation Subset:  AIM; IM    
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
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MeSH Terms
Fetal Blood / parasitology
Fetal Growth Retardation*
Malaria, Falciparum / complications*
Malawi / epidemiology
Obstetric Labor, Premature*
Placenta / parasitology
Pregnancy Complications, Parasitic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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